Squamous cell carcinoma - Squamous Zell Carcinoma
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Squamous cell carcinoma well differentiated ― Eng ugrenzend aktinesch Keratose gëtt beobachtet.
References
Squamous cell carcinoma (SCC) ass den zweet heefegste Hautkriibs an den USA, no basal cell carcinoma. Et fänkt normalerweis aus precancerous lesions genannt actinic keratosis , a kann op aner Deeler vum Kierper verbreet. D'Haaptursaach ass Belaaschtung fir ultraviolet (UV) Stralung vun der Sonn, déi sech mat der Zäit accumuléiert. D'Behandlung beinhalt normalerweis chirurgesch Entfernung, besonnesch fir SCC um Kapp an Hals. Bestrahlungstherapie ass eng Optioun fir eeler Patienten oder déi déi keng Chirurgie kënnen hunn. Immunosuppressioun erhéicht de Risiko vu SCC. Obwuel seelen, kann SCC verbreet, besonnesch bei Patienten mat geschwächt immun Systemer. Regelméisseg Kontrollen a Sonneschutz si wichteg fir déi mat SCC.
Squamous cell carcinoma of the skin or cutaneous squamous cell carcinoma is the second most common form of skin cancer in the United States, behind basal cell carcinoma. Squamous cell carcinoma has precursor lesions called actinic keratosis, exhibits tumor progression and has the potential to metastasize in the body. Ultraviolet (UV) solar radiation is the primary risk factor in the development of cutaneous squamous cell carcinoma and the cumulative exposure received over a lifetime plays a major part in the development of this cancer. Surgical excision is the primary treatment modality for cutaneous squamous cell carcinoma, with Mohs micrographic surgery being the preferred excisional technique for squamous cell carcinoma of the head and neck, and in other areas of high risk or squamous cell carcinoma with high-risk characteristics. Radiation therapy is reserved for squamous cell carcinoma in older patients or those who will not tolerate surgery, or when it has not been possible to obtain clear margins surgically. Adjuvant radiotherapy is commonly after surgical treatment in very high tumors. Immunosuppression significantly increases the risk of squamous cell carcinoma over the course of an individual’s life. Metastasis is uncommon for squamous cell carcinomas arising in areas of chronic sun exposure, but it can take place, and the risk is increased in immunosuppressed patients. Patients with cutaneous squamous cell carcinoma should be examined regularly and remember to use measures to protect from UV damage.
Squamous cell carcinoma of the skin or cutaneous squamous cell carcinoma is the second most common form of skin cancer in the United States, behind basal cell carcinoma. Squamous cell carcinoma has precursor lesions called actinic keratosis, exhibits tumor progression and has the potential to metastasize in the body. Ultraviolet (UV) solar radiation is the primary risk factor in the development of cutaneous squamous cell carcinoma and the cumulative exposure received over a lifetime plays a major part in the development of this cancer. Surgical excision is the primary treatment modality for cutaneous squamous cell carcinoma, with Mohs micrographic surgery being the preferred excisional technique for squamous cell carcinoma of the head and neck, and in other areas of high risk or squamous cell carcinoma with high-risk characteristics. Radiation therapy is reserved for squamous cell carcinoma in older patients or those who will not tolerate surgery, or when it has not been possible to obtain clear margins surgically. Adjuvant radiotherapy is commonly after surgical treatment in very high tumors. Immunosuppression significantly increases the risk of squamous cell carcinoma over the course of an individual’s life. Metastasis is uncommon for squamous cell carcinomas arising in areas of chronic sun exposure, but it can take place, and the risk is increased in immunosuppressed patients. Patients with cutaneous squamous cell carcinoma should be examined regularly and remember to use measures to protect from UV damage.
Cutaneous squamous cell carcinoma (CSCC) ass den zweet heefegste Kriibs bei Leit, a seng Zuelen ginn erop. Och wann CSCC normalerweis e benign klinescht Verhalen affichéiert, kann et souwuel lokal wéi an aner Deeler vum Kierper verbreeden. Wëssenschaftler hunn spezifesch Weeër identifizéiert, déi an der CSCC Entwécklung involvéiert sinn, wat zu neie Behandlungen féiert. Déi héich Zuel vu Mutatiounen a erhéicht Risiko bei immunosuppresséierte Patienten hunn d'Entwécklung vun der Immuntherapie gefuerdert. Dës Iwwerpréiwung kuckt op d'genetesch Wuerzelen vum CSCC an déi lescht Behandlungen, déi spezifesch Molekülen an den Immunsystem zielen.
Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans and its incidence continues to rise. Although CSCC usually display a benign clinical behavior, it can be both locally invasive and metastatic. The signaling pathways involved in CSCC development have given rise to targetable molecules in recent decades. In addition, the high mutational burden and increased risk of CSCC in patients under immunosuppression were part of the rationale for developing the immunotherapy for CSCC that has changed the therapeutic landscape. This review focuses on the molecular basis of CSCC and the current biology-based approaches of targeted therapies and immune checkpoint inhibitors
Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans and its incidence continues to rise. Although CSCC usually display a benign clinical behavior, it can be both locally invasive and metastatic. The signaling pathways involved in CSCC development have given rise to targetable molecules in recent decades. In addition, the high mutational burden and increased risk of CSCC in patients under immunosuppression were part of the rationale for developing the immunotherapy for CSCC that has changed the therapeutic landscape. This review focuses on the molecular basis of CSCC and the current biology-based approaches of targeted therapies and immune checkpoint inhibitors
○ Diagnos a Behandlung
#Dermoscopy
#Skin biopsy